A total of 32 sets of prostatic tissue biopsy samples were evaluated from nine dogs with prostatic neoplasia (Fig. 2; for one dog, only S100A12+ cell counts were evaluated due to insufficient tissue available for paired evaluation of the S100A8/A9+ cell counts), eight dogs with severe prostatitis (Fig. 3), ten dogs with BPH (Fig. 4), and five dogs comprising the control group. The gene discussed is IGKV1D-22; the disease is benign prostatic hyperplasia.