The NLR was strongly correlated with the number of S100A8/A9+ cells in prostatic tissue biopsies from dogs with prostatic neoplasia (ρ = 0.81, P = 0.0499) and the numbers of prostatic tissue S100A12+ cells in dogs with BPH (ρ = 0.93, P = 0.0025), but not with any S100/calgranulin-positive cell counts in dogs with marked prostatitis (all P > 0.05). The gene discussed is IGKV1D-22; the disease is male reproductive organ cancer.