A total of 32 sets of prostatic tissue biopsy samples were evaluated from nine dogs with prostatic neoplasia (Fig. 2; for one dog, only S100A12+ cell counts were evaluated due to insufficient tissue available for paired evaluation of the S100A8/A9+ cell counts), eight dogs with severe prostatitis (Fig. 3), ten dogs with BPH (Fig. 4), and five dogs comprising the control group. Here, S100A8 is linked to male reproductive organ cancer.