ERBB2 and gastroesophageal junction adenocarcinoma: Currently, Fam-trastuzumab deruxtecan-nxki (Vidextus) has been approved for the treatment of locally advanced or metastatic gastric cancer (including adenocarcinoma of the gastroesophageal junction) with HER2 overexpression, which has previously undergone at least 2 systemic therapies [10].