The differentially expressed genes analysis of preneoplastic lesions versus normal tissue only yielded 3 genes with an adjusted p-value less than or equal to 0.05, including Prom1, Cdkn2b, and Ngf. In contrast, the comparison of EV-injected samples with tumours detected 59 significantly differentially expressed genes with an adjusted p-value less than or equal to 0.05. This evidence concerns the gene PROM1 and neoplasm.