Discordant interpretations exist for 229 variations in Hypertrophic Cardiomyopathy, with the majority of these variations located in well-known cardiomyopathy-related genes such as MYBPC3 (68 variations), MYH7 (49 variations), TNNI3 (20 variations), or TNNT2 (20 variations). Here, MYBPC3 is linked to cardiomyopathy.