The HALT Progression of Polycystic Kidney Disease study concluded that strict blood pressure control with blockade of the renin-angiotensin system was associated with a slower kidney volume increase and greater reduction in the left ventricular mass index and urinary albumin excretion [23], shedding light on the blood pressure target of patients with ADPKD. Here, REN is linked to autosomal dominant polycystic kidney disease.