GLS and cancer: At present, specific inhibitory of GLS1, such as Bis-2-[5-(phenylacetamido)-1,3,4-thiadiazol-2-yl]ethyl sulfide (BPTES) or its analogs (for example, N-(5– [1, 3, 4]thiadiazol-2-yl)-2-phenyl-acetamide 6) had been used as molecular probes to justify the efficacy of GLS1 inhabitory in many cancers [31, 32].