In univariate analysis, Patients were older (P < 0.001), combined HF (P < 0.001), CHD (P = 0.003), cancer (P < 0.001), HA-AKI (P < 0.001), sepsis (P < 0.001), critical AKI (P < 0.001), lower baseline Scr (P = 0.002), higher Glu (P < 0.001), higher alkaline phosphatase (ALP) (P = 0.004), lower MCHC (P < 0.001), lower Hb (P = 0.005), higher CRP (P = 0.023), higher BNP (P < 0.001), higher RDW (P < 0.001) was independently associated with an increased risk of death. This evidence concerns the gene NPPB and acute kidney injury.