Consistent with the connection between MYC and SLC5A6 observed in the preclinical models, we saw a clear correlation between higher grade, ER-negative and MYC signature-high tumors and the SLC5A6 transporter (Fig. 4m) in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset of breast cancer samples37. This evidence concerns the gene ESR1 and breast carcinoma.