Consistent with the connection between MYC and SLC5A6 observed in the preclinical models, we saw a clear correlation between higher grade, ER-negative and MYC signature-high tumors and the SLC5A6 transporter (Fig. 4m) in the Molecular Taxonomy of Breast Cancer International Consortium (METABRIC) dataset of breast cancer samples37. Here, SLC5A6 is linked to breast carcinoma.