These studies established that CLL cells move to lymph node follicles in a CXCR5-dependent manner and interact with follicular stromal cells through lymphotoxin beta receptor (LTβR), causing in CXCL13 production by the lymph node stroma, followed by CLL cell activation and proliferation [20]. Here, CXCR5 is linked to B-cell chronic lymphocytic leukemia.