LGALS9 and B-cell chronic lymphocytic leukemia: Also, Pang et al. showed that the binding of galectin-9 and Tim-3 on T regulatory cells (Treg) enhanced Treg cell function while reducing Th1 and CD4 + T cell function, which has been restored in CLL in vitro tests by blocking the galectin-9/Tim-3 pathway [26].