To determine the effectiveness of our AEC approach in vivo, we transduced the multiple myeloma (MM) cell line U266 with retroviral vectors encoding truncated Her2 or EGFR, lacking the intracellular signaling domains (U266-tHer and U266-tEGFR) to rule out unwanted effects of Her2 or EGFR signaling. Here, ERBB2 is linked to AL amyloidosis.