INS and pancreatic insulinoma: To identify small molecules that acutely enhance insulin secretion from β cells, we performed a focused chemical screen using the mouse insulinoma β cell line (MIN6) carrying a proinsulin-NanoLuc reporter (NLuc-MIN6)9 with chemicals from an in-house chemical library containing 223 compounds targeting different signaling pathways (Supplementary Tables 1 and 2).