VAPB and amyotrophic lateral sclerosis: A possible role for VAPB in cancer and ALS is further substantiated by the fact that VAPB interacts with Ephrin receptors12, which are key players in the development of the Central Nervous System (CNS) as well as in adult tissue homeostasis and which make up a large family of tyrosine kinase receptors13 that have been associated with both cancer and ALS14.