We also investigated the molecular pathways deregulated in medulloblastoma cells when VAPB is absent and observed that VAPBKO in medulloblastoma cells results in increased phosphorylation of the EPHA4 receptor, as well as deregulated expression of WNT-regulated genes, both pathways with an established role in neurodevelopment15,37,38. The gene discussed is VAPB; the disease is medulloblastoma.