ORAI2 and breast carcinoma: As shown in Fig. 1A, we have found that the breast cancer stem cells (BCSC) derived from MCF7, SKBR3 and MDA-MB-231 breast cancer cell lines overexpressed Orai1 and Orai2 as compared to breast stem cells (BSC) derived from the non-tumoral cell line MCF10A (p < 0.001; n=6).