BCSC isolated from the SKBR3 cell line show null expression of TRPC1 while overexpression TRPC3 and TRPC6 (Fig. 1A; p < 0.001; n=6); meanwhile, BCSC-derived from the triple negative breast cancer cell line MDA-MB-231 exhibit a significantly greater expression of TRPC1 (Fig. 1A; p < 0.001; n=6) while the expression of TRPC3 and TRPC6 was similar to that observed in MCF10A-derived BSC. Here, TRPC1 is linked to triple-negative breast carcinoma.