HNLN lymphocytes were subsequently stimulated in vitro with anti-CD3 plus anti-CD28 mAbs, and collected culture supernatants from LL 301-treated SjS females showed significantly reduced levels of IFN-γ, IL-6, IL-17, IL-21, and GM-CSF relative to those T cells from PBS controls (Fig. 6F–J). This evidence concerns the gene IFNG and Schwartz-Jampel syndrome.