Our results showed that the TLR1-N248 polymorphism (HR = 1.694, 95% CI = 1.063–2.698, p = 0.027) was an independent prognostic factor of DMFS for locally advanced COAD patients (Table 3), indicating that the TLR1-N248 polymorphism has significant prognostic value for COAD patients with regional lymph node metastasis. The gene discussed is TLR1; the disease is colon adenocarcinoma.