APLN and cancer: These differentially expressed genes (DEGs) (Supplementary Fig. 2B,C) were significantly enriched in proteoglycans in cancer, Hippo signaling pathway, hedgehog signaling pathway, and apelin signaling pathway for KEGG term, and regulation of DNA metabolic process, negative regulation of hippo signaling, and epithelial to mesenchymal transition (Supplementary Fig. 2D,E).