CD8A and neoplasm: Using flow cytometry, we substantiated that free EPA was capable of eliciting CTL responses via activation of the DCs (increased CD80+/CD86+) and CD11c+/CD103+, upregulation of IFN-γ+ or Granzyme B+ CD8+ T cells, and dampening of Foxp3+ Tregs and granulocytes MDSC (G-MDSC) as well as repolarization of the TAM (enhanced M1/M2 ratios) immunosuppressive effects in tumours (Fig. 4h–n)46,49.