Finally, the multifaceted pathogenesis of CRC is influenced by a myriad of factors, including miRNAs such as miR-646, miR-665, and miR-526b-3p, which regulate gene expression and form complex ceRNA networks with circRNAs like hsa_circ_000240, impacting the regulation of target genes, and interacting with hub genes like CDC6 and ORC1 vital for DNA replication and epigenetic regulation. The gene discussed is ORC1; the disease is colorectal carcinoma.