For example, cytoplasmic TDP-43 droplets may recruit and mislocalize importin-α, Nup62, RanGAP1, Ran, and Nup107, leading to inhibition of nuclear transport and eventual neuronal cell death.443 Likewise, pathogenic Tau can lead to NPC dysfunction by directly interacting with NPC components, causing their mislocalization.444 Therefore, current studies support the existence of a vicious cycle in NDD, i.e., the progressive deterioration of RBP localization and nuclear transport (Fig. 9). Here, NPC1 is linked to Neurodevelopmental delay.