TARDBP and neurodegenerative disease: Some importin-chaperoned HBCs are the neurodegenerative disease-associated RBPs, including FUS, TAF15, hnRNP A1/A2, and TDP-43.278 These RBPs are typically larger and contain RNA recognition motif (RRM) domains, intrinsically disordered low complexity (LC) regions, and arginine-glycine-glycine rich (RGG) domains.