XPO1 and B-cell chronic lymphocytic leukemia: Notably, the XPO1 E571K mutation is present in a quarter of patients with Hodgkin lymphoma and primary mediastinal B-cell lymphoma.410 Moreover, E571K accelerated leukemogenesis in a mouse model of chronic lymphocytic leukemia.389 This mutation altered XPO1 localization and the interactome of XPO1 in B-cell lymphoma.411 Structurally, E571 is located proximal to the NES groove, and the E571K mutation can increase the affinity for XPO1 cargoes that have more acidic residues in the NES sequence.412