STING1 and neoplasm: Beyond this tumor-intrinsic function, STING plays a fundamental role also in non-tumor cells where STING Dependent Adjuvants (STAVs) (DNA of dying tumor cells, cGAMP, oncolytic viral DNA) can activate antigen presenting cells by phagocytosis53 as well as by transfer via gap junctions to tumor-associated dendritic cells (DCs) and macrophages, which respond by producing type I interferons in situ54.