Besides those roles inherent to DNA sensing, the functionality of STING in both tumor and non-tumor compartments may play roles the in elicitation of anti-tumor immunity in response to checkpoint inhibition (i.e., PD-1 and CTLA-4), as a possible consequence to sensing of cytoplasmic DNA generated by genotoxic stresses or chromosome instability48. The gene discussed is STING1; the disease is neoplasm.