Take T cell as an example (Fig. 4C), among the genes that show alternative-TSS activation in NPC, multiple of them are well-known cancer-related biomarkers such as QSOX1 serving as a prognosis biomarker in breast cancer37, DTNBP1 relating with memory and executive functions in brain tumor38, and FAM107B associated with gastric cancer39. This evidence concerns the gene FAM107B and nasopharyngeal carcinoma.