The expression of 5D4‐KSPG is elevated within a specific subgroup of microglia that are positive for IBA1/CD11b in the context of amyotrophic lateral sclerosis (ALS) and in a Wallerian degeneration mouse model for spinal cord injury [57, 127, 128]. The gene discussed is ITGAM; the disease is amyotrophic lateral sclerosis.