The association of AGR3 with the positivity of estrogen and progesterone receptors demonstrates that there is a close relationship between AGR3 and the luminal subtypes.5, 11, 13This interaction has often been reported10, 11, 13, 14and, in conjunction with the other histological and proliferative characteristics, it suggests that AGR3 is associated with less aggressive cancers that are generally responsive to treatment and therefore have a favorable result.5 Here, AGR3 is linked to cancer.