EGR1 and cancer: We also tested genes based on their proximity to Cdkn1a expression in senescence pathways (Cdkn2a and Trp53; (Childs et al., 2015)) or their connection to senescence in cancer models (Egr1 and Gadd45α (Krones-Herzig et al., 2003; Wang et al., 2021; Wang et al., 1999)).