AHR and ulcerative colitis: Overlaying our RNAseq data set with data sets from ulcerative colitis vs. control patients, gene set enrichment analysis identified a significant overlap of DEGs between control and AHR inhibitor–treated organoids with genes down-regulated in UC patient-derived organoids (Supplementary Figure 3A) and genes of the epithelium of UC patients from both inflamed and noninflamed tissue (Supplementary Figure 3B).