In addition, p.Ala654Thr and p.Ala654Asp heterozygous GRID2 variants were identified in patients from different families with congenital spinocerebellar ataxia, and either heterozygous or homozygous missense p.Leu656Val variants in GRID2 have been reported in multiple patients from a large family with cerebellar ataxia [41]. This evidence concerns the gene GRID2 and aceruloplasminemia.