While the impact of greater numbers of intratumoral naïve CD8+ T cells in YOPC is unclear, higher circulating levels of these cells have been associated with improved prognosis in other solid tumors, for example, non–small-cell lung cancer.45 These findings underscore the need for deeper investigation and functional characterization of cell-autonomous and nonautonomous immunologic repercussions in YOPC tumors. The gene discussed is CD8A; the disease is lung cancer.