In terms of laboratory findings, fibrinogen levels of patients in the AP group were significantly lower than those of patients in the HPE group, while ALT, AST, ALP, GGT, LDH, amylase, lipase, CK, CK-MB, troponin I, BNP, APTT, TT, CRP, IL-6, procalcitonin, ESR levels and viral load were significantly higher in the AP group than those in the HPE group. The gene discussed is NPPB; the disease is holoprosencephaly.