Among these laboratory parameters, serum fibrinogen levels of patients in the HPE group were identified to be significantly lower than those of patients in the normal and EPE groups, while ALT, AST, ALP, LDH, creatinine, cystatin C, CK, troponin I, APTT, D-dimer, procalcitonin and IL-6 levels were significantly higher in the HPE group. Here, IL6 is linked to holoprosencephaly.