FZD7 and breast neoplasm: Indeed, treatment with cisplatin increased expression of basal/mesenchymal genes, as well as Fzd7 in MMTV-PyMT tumors, whereas these changes were reduced in the presence of TcdBFBD (Fig 6H), suggesting that cisplatin-induced cell fate change renders cells sensitive to the co-inhibition of FZD7-mediated Wnt signaling in luminal breast tumors.