RNF43 and neoplasm: We found TcdBFBD-treated p53/BRCA1-deficient tumor organoids exhibited reduced expression of Wnt signaling-related genes (e.g., Axin2, Rnf43) and EMT-related genes (e.g., Vim, Zeb1) compared with the control and TcdBmu-treated organoids (S11A Fig).