ALDH2 and esophageal squamous cell carcinoma: The previous report by our team regarding the association of BRCA2 p.K3326* mutation with ESCC risk [26] and our new finding of the considerable ESCC risk modifying effect of the ALDH2-rs10744777 TT genotype among BRCA2 p.K3326* carriers signify the importance of determining genetically high-risk individuals for ESCC, so that we can address individualized preventive strategies and further help to reduce ESCC incidence in northeastern Iran.