After adjusting for age, gender, ethnicity, smoking, alcohol drinking and opium use, BRCA2 p.K3326* carriers had a 5.66-fold elevated risk of developing ESCC compared to non-carriers with TT genotype of the ALDH2 rs10744777 (OR = 5.66, 95% CI = 1.22–26.2, P = 0.018) (Table 3). This evidence concerns the gene ALDH2 and esophageal squamous cell carcinoma.