BRCA2 and cancer: They observed that aldehydes, including formaldehyde and acetaldehyde, can induce BRCA2 haploinsufficiency by triggering proteasomal degradation of the BRCA2 wild-type proteins in cells heterozygous for a pathogenic BRCA2 truncating mutation and predispose them to DNA repair anomalies, genomic instability, and possibly cancer [29].