INSR and diabetes mellitus: Concerning GO molecular function, the up-regulated DEG signatures were significantly enriched in growth factor binding such as insulin receptor binding and carbohydrate derivative binding as far as down-regulated DEG signatures were concerned these DEGs were significantly enriched in hormone binding, vascular endothelial growth factor, and transcription factor binding portraying a vital role in the occurrence and progression of type 2 diabetes mellitus vasculopathy [62].