GCG and Insulin resistance: The primaries revealed that the vast majority of the biological processes and pathways correlate with diabetic vasculopathy, precisely in altered vascular permeability, tetrahydrofolate metabolic pathway, fatty acid metabolic pathway, insulin resistance, pancreatic cancer, glucagon signaling pathway, diabetic comorbidities including obesity signifying that these signaling pathways possibly are the primary contributors to the vasculopathy in type 2 diabetic mellitus [64].