To establish the diagnostic potential of HSP90 in clinical scenario, we compared the serum levels of HSP90 alpha and beta in HNSCC (N = 14, Mean age: 59.2±12.7 years) and HC (N = 32, Mean age: 52.2±16.2 years) (Table 1). Here, HSP90AB1 is linked to head and neck squamous cell carcinoma.