We failed to identify any known variants linked to inherited neurological or metabolic disorders, but rather noted 3 variants linked to the same protein complex/pathway, namely SEL1L-HRD1 ERAD: SEL1L p.Gly585Asp (NM_005065: exon 17: c.1754G>A) in the Saudi Arabian patient (patient 1), SEL1L p.Met528Arg (exon 16: c.1583T>G) in the Moroccan patients (patient 2 and 3), and HRD1 p.Pro398Leu (NM_172230: exon 12: c.1193C>T) in the Italian patient (patient 6) (Figure 1, D–F, and Table 1). This evidence concerns the gene SYVN1 and metabolic disease.