SLC16A7 and malnutrition: This led to a significant increase in lactate content in the tumor, which in turn accelerated the acidification of TAMs and prompted their polarization toward the M2 pro-tumor phenotype.78 As a result, MCT-2 can be considered a significant biomarker.97 Furthermore, Chao et al. discovered that malnutrition may have specific modulatory effects on certain microbiota, thereby remodeling the intestinal microenvironment in CRC and accelerating associated tumor progression.