This led to a significant increase in lactate content in the tumor, which in turn accelerated the acidification of TAMs and prompted their polarization toward the M2 pro-tumor phenotype.78 As a result, MCT-2 can be considered a significant biomarker.97 Furthermore, Chao et al. discovered that malnutrition may have specific modulatory effects on certain microbiota, thereby remodeling the intestinal microenvironment in CRC and accelerating associated tumor progression. This evidence concerns the gene SLC16A7 and colorectal carcinoma.