This was achieved through the downregulation of interferon regulatory factor 1 (IRF1) and hypoxia-inducible factor 1-α (HIF-1α) via the microRNA-142a(miR-142a)-IRF1/HIF-1α pathway and the inhibition of iNOS expression.74 Wu et al. conducted a study to investigate the impact of AHR activation or overexpression on neuroblastoma progression and its potential as a prognostic biomarker. The gene discussed is IRF1; the disease is neuroblastoma.