Previous studies have shown that dietary Pi supplementation improves bone growth and mineralization in 3- to 7-week-old Dmp1-null mice (5, 37) and that anti-FGF23 antibodies correct hypophosphatemia and bone mineralization in 1- to 4-week-old Dmp1-null mice (37, 38). This evidence concerns the gene FGF23 and hypophosphatemia.