While the role of DMP1 as a pro-mineralization factor is well documented (20, 45, 46), its direct contribution in the pathogenesis of impaired mineralization in ARHR is less clear, as most effects are attributed to failure of DMP1 to suppress FGF23 and FGF23-induced hypophosphatemia. The gene discussed is DMP1; the disease is autosomal recessive hypophosphatemic rickets.