Renal fibrosis-associated transcripts (Liu et al., 2017), including matrix metalloproteinase-1 (MMP1), matrix metalloproteinase-7 (MMP7), matrix metalloproteinase-9 (MMP9), serpin family E member 1 (SERPINE1) and many collagens (COL6A5, COL6A6, COL7A1, COL8A1, COL15A1, COL19A1 and COL21A1), were also elevated in the CFH-treated organoid group (Table S2). This evidence concerns the gene COL21A1 and renal fibrosis.