KLK3 and posterior cortical atrophy: A recent systematic review and meta-analysis evaluated all the studies investigating the main salvage treatments in the management of locally recurrent PCa, finding no significant differences in recurrence-free survival between different techniques.6 Regarding hormonal therapy for PSA-recurrence after RT, the 2021 EAU guidelines for PCa recommend not offering androgen deprivation therapy to M0 patients with a PSA-doubling time >12 months.5