Among VGKC, different members (Kv1.3, Kv3.1, Kv3.4, Kv4.2, Kv5.1, Kv7.1, Kv9.3, Kv10.1, and Kv11.1) are involved in LC cell proliferation, migration and invasion (Jang et al., 2011a; Restrepo-Angulo et al., 2011; Glassmeier et al., 2012; Girault et al., 2014; Acuña-Macías et al., 2015; Lee et al., 2015; Chen et al., 2023) and some of them (Kv1.3, Kv4.2, and Kv7.1) have clinical relevance in NSCLC (Girault et al., 2014; Lu X. et al., 2021; Chang et al., 2022; Angi et al., 2023) (Table 4). This evidence concerns the gene KCND2 and non-small cell lung carcinoma.