Among Chloride channels (Figure 1), three members have been shown to be expressed in NSCLC cells: the Chloride Voltage-gated channel 3 (ClC-3), functioning as a Chloride-Hydrogen antiporter (associated to MDR) (Chen et al., 2019), CLIC1 (that mediates cell survival) (Lee et al., 2019) and VRAC (involved in Carboplatin-induced apoptosis) (He et al., 2010) (Table 4). Here, CLCN3 is linked to non-small cell lung carcinoma.