Thus, in the setting of impaired insulin and glucagon responses to hypoglycemia, recurrent hypoglycemia induces a syndrome of Hypoglycemia Associated Autonomic Failure (HAAF) that is composed of an impaired awareness of hypoglycemia (IAH) and a blunted counterregulatory response (Davis et al., 2000). The gene discussed is GCG; the disease is Hypoglycemia.