For example, the HypoCOMPaSS trial (Comparison of Optimized MDI versus Pumps with or without sensors in severe hypoglycemia) (Cox et al., 2006) demonstrated improvements in hypoglycemia awareness and reduction in severe hypoglycemia with intensive hypoglycemia-focused education and close monitoring program, with non-differential effects between groups using more traditional or advanced glucose monitoring and insulin administration technologies (Yeoh et al., 2015). Here, INS is linked to Hypoglycemia.