Interestingly, bothRPL13A andCYC1 (Cytochrome C1) were identified as suitable reference genes in a study of 98 brain samples from two regions (prefrontal cortex and cerebellum) from human patients with neurodegenerative diseases (Alzheimer's disease, Parkinson's disease, Multiple System Atrophy, and Progressive Supranuclear Palsy) (Rydbirket al., 2016).CYC1 encodes a protein that forms part of the mitochondrial electron transport chain and is crucial in cellular respiration (Schaggeret al., 2004). The gene discussed is CYC1; the disease is progressive supranuclear palsy.