PLAT and Pleural effusion: Kheir and colleagues [12] compared sequential vs. concurrent treatment with tPA and DNase (a total of 38 patients, 18 patients received tPA/DNase sequentially, and 20 patients received the dose concurrently); there was no statistically significant difference between the two treatment groups in median pleural fluid drainage or median volume of pleural effusion estimated on chest computed tomography scan.