Hypoxia could induce the expression of induce the expression of hypoxia-induced long non-coding RNA associated with RCC (lncHILAR), which functions as a competing endogenous RNA (ceRNA) for miR-613/206/1-1-1-3p and competitively activates the Jagged1/Notch/CXCR4 pathway, thereby promoting invasion and migration of RCC in vitro and metastasis in vivo. This evidence concerns the gene JAG1 and renal cell carcinoma.