TGFB1 and nonpapillary renal cell carcinoma: ccRCC-exo significantly activated macrophage conversion to M2-type phenotype, which led to increased expression levels of TGFβ and IL-10 in macrophages, which, in turn, promoted the migration of ccRCC cells, suggesting that exosome AP000439.2 may be a new therapeutic target for ccRCC (33).