However, in the joint analysis of all three HLA class I loci (HLA-A, -B, and -C) together, there was a 26% reduction in the odds of developing CRC for subjects with heterozygous genotypes at all 3 loci when compared to those with all homozygous genotypes (OR: 0.74, 95% Confidence Interval (CI): 0.56-0.97, p=0.0314; Table 2). Here, HLA-A is linked to colorectal carcinoma.