Of note, although XCR1 RO was observed in the tumor and correlated with increased targeted IFN activity in tumor cDC1s compared to isotype control, XCR1 RO and IFN activity induced by the isotype control was much more prominent in the spleen compared to the tumor, likely due to increased drug exposure in the spleen compared to tumor. The gene discussed is XCR1; the disease is neoplasm.