Notably, ABI3 expression exhibited a positive correlation with the degree of infiltration by CD4+ T cells, CAF, Endo, HSC, γ/δT, NK T cells, Tregs, B cells, Monocytes, and CD8+ T cells in the majority of cancers, suggesting that ABI3 potentially influences cancer progression and outcome by modulating the tumor microenvironment. The gene discussed is CD8A; the disease is neoplasm.