AD risk genes such as TREM2, ABCA7, CD33, MS4A6A, CR1, INPP5D, BIN1, PICALM, EPHA1, CD2AP, SORL1, and RIN3 are tightly linked to Aβ clearance via the endo-lysosomal pathway (Hansen et al., 2018; Lambert et al., 2022). This evidence concerns the gene PICALM and Alzheimer disease.