HEPH and mesothelioma: One of the most striking differences was the one recorded for SNP rs3747359 in the Hephaestin (HEPH) gene; in our three sample sets, as well as in the subgroup of healthy Italians contained in the 1000 genomes database and even in the European populations described in (39), only allele G was identified, thus representing a non-polymorphic marker, while in the paper by Crovella et al. allele C reached the remarkable frequency of 37% in the set of individuals exposed to asbestos who did not develop mesothelioma.