CDKN2A and neoplasm: The present study is intended to observe the prevalence of p16 expression and its association with tumor grade and muscle invasiveness in urothelial carcinoma of the urinary bladder among the patients undergoing treatment at a tertiary care facility of Chattogram city in Bangladesh which may help to determine the prognosis of patients in our population and can open a door for planning newer therapeutic strategies for the patients who are resistant to traditional therapies.