Indeed, magnetic resonance imaging (MRI) has revealed white matter deficits and inflammation in asymptomatic individuals who later progress to AD (Brickman et al., 2015; Caballero et al., 2018; Wang et al., 2019) and an association between white matter damage and classical amyloid-β (Aβ) and phosphorylated tau (p-tau) pathology (Dean et al., 2017; Wang et al., 2019). The gene discussed is MAPT; the disease is Alzheimer disease.