Nevertheless, a great diversity of focal neurologic findings have been reported in DIAD, including visual agnosia, spastic paraplegia, ataxia, aphasia and behavioural changes.16 Post-mortem studies comparing the burden of Alzheimer’s disease pathology in early-onset and late-onset patients demonstrate a higher overall burden of neurofibrillary tangles (to a greater degree than neuritic plaques) and more severe neurodegeneration in younger patients,25-34 and similar results have been reported with tau PET and structural MRI when comparing DIAD with LOAD cohorts.17,35,36. This evidence concerns the gene MAPT and Alzheimer disease.